Frequently Asked Questions

Quick answers to common questions about peptide research.

General Questions

What are peptides?

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Peptides are short chains of amino acids (typically 2-50) linked by peptide bonds. They're essentially small proteins that act as signaling molecules in the body. Research peptides are synthetic versions used to study specific biological effects.

Are peptides legal?

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Most peptides are legal to purchase for research purposes in the US and many other countries. They must be labeled "for research use only" and are not approved for human use. Some peptides like Semaglutide are prescription medications with different regulations. Always verify current laws in your jurisdiction.

What's the difference between peptides and proteins?

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The main difference is size. Peptides contain 2-50 amino acids, while proteins contain 50+ amino acids and have more complex 3D structures. Peptides are generally smaller, simpler, and often act as signaling molecules rather than structural components.

Sourcing Questions

How do I know if a peptide vendor is reliable?

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Look for vendors that provide: third-party testing with batch-specific COAs, HPLC purity results (>98%), mass spectrometry verification, transparent business practices, and proper "research use only" labeling. Avoid vendors making medical claims or offering prices significantly below market rates.

What is a COA and why does it matter?

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A Certificate of Analysis (COA) is a document from a testing laboratory that verifies a peptide's identity and purity. It should include HPLC purity percentage, mass spectrometry data confirming molecular weight, and batch number. Third-party COAs (from independent labs) are more reliable than in-house testing.

Why are some peptides more expensive than others?

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Price varies based on: amino acid sequence length and complexity, synthesis difficulty, purity level (higher purity costs more), demand and availability, and vendor overhead. Longer, more complex peptides cost more to manufacture. Very low prices often indicate quality compromises.

Storage & Handling

How should I store lyophilized peptides?

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Lyophilized (freeze-dried) peptides should be stored at -20°C (freezer) for long-term storage, or 2-8°C (refrigerator) for short-term (weeks). Keep them sealed, protected from light and moisture. In proper conditions, lyophilized peptides remain stable for months to years.

How long do reconstituted peptides last?

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When reconstituted with bacteriostatic water and refrigerated (2-8°C), most peptides remain stable for 2-4 weeks. Some peptides like BPC-157 are more stable; others degrade faster. Avoid freezing reconstituted peptides as freeze-thaw cycles can damage them.

What is bacteriostatic water?

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Bacteriostatic water is sterile water containing 0.9% benzyl alcohol as a preservative. It inhibits bacterial growth, allowing reconstituted peptides to remain stable longer. Regular sterile water can be used but the solution should be used within 24-48 hours.

How do I reconstitute a peptide?

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1) Allow the vial to reach room temperature, 2) Clean the vial stopper with alcohol, 3) Draw bacteriostatic water into a syringe, 4) Slowly inject water down the vial wall (not directly onto the powder), 5) Gently swirl (don't shake) until dissolved, 6) Calculate your concentration based on water volume added.

Research Questions

What's the difference between GHRP and GHRH peptides?

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GHRPs (Growth Hormone Releasing Peptides) amplify the GH release signal by stimulating the ghrelin receptor. GHRHs (Growth Hormone Releasing Hormones) trigger GH release from the pituitary. They work through different mechanisms and are synergistic—using both together produces significantly more GH release than either alone.

What's the difference between BPC-157 and TB-500?

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BPC-157 is a gastric peptide that works more locally, promoting angiogenesis and healing at specific sites. TB-500 (Thymosin Beta-4) works systemically throughout the body, promoting cell migration and reducing inflammation. They have different mechanisms and are often used together for complementary effects.

Do peptides need to be cycled?

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It depends on the peptide. Some like Epithalon are typically used in cycles (10-20 days on, months off). GH secretagogues may be used continuously or cycled. Healing peptides like BPC-157 are usually used for specific durations matching healing needs. There's no universal rule—protocols vary by compound and research goals.

What does "mcg" mean?

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Mcg stands for micrograms (also written as μg). One milligram (mg) equals 1,000 micrograms (mcg). Peptide doses are typically measured in mcg because they're used in small amounts. For example, a common Ipamorelin dose is 200-300 mcg, or 0.2-0.3 mg.

Safety Questions

Are peptides safe?

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Most research peptides have relatively favorable safety profiles in studies, but they are not FDA-approved for human use. Long-term effects are often not fully established. Individual responses vary. Anyone considering peptide use should consult healthcare professionals and understand that they are research compounds.

Can peptides interact with medications?

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Yes, peptides can potentially interact with medications. For example, GLP-1 agonists affect blood sugar and may interact with diabetes medications. GH-releasing peptides may affect insulin sensitivity. Always disclose peptide use to healthcare providers and never combine with medications without professional guidance.

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